Sunday 5 January 2014

Diabetes Risk May Come from Neanderthal Gene

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A girl goes nose-to-nose with a Neanderthal statue in Germany. Ancient DNA research is increasingly revealing the genetic links between modern humans and our extinct ancestors, including Neanderthals and the mysterious Denisovans.
  Mexicans and other Latin Americans have a higher risk of diabetes because of a Neanderthal gene mutation, researchers say.
These findings could uncover new targets for diabetes drugs, investigators added.
An international team of researchers focused on Type 2 diabetes, the most common form of the disease, accounting for 90 percent to 95 percent of diabetes cases in humans. In Type 2 diabetes, the body either does not generate enough insulin or its cells ignore the molecule. Insulin is a hormone the body needs in order to use sugar for energy.


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Car in Paul Walker crash may have been traveling 100 mph, coroner's report says


Sheriff's deputies work near the wreckage of a Porsche that crashed into a light pole on Hercules Street near Kelly Johnson Parkway in Valencia, Calif., killing actor Paul Walker on Saturday, Nov. 30, 2013. (Dan Watson / The Santa Clarita Valley Signal via AP)


Sheriff's deputies work near the wreckage of a Porsche that crashed into a light pole on Hercules Street near Kelly Johnson Parkway in Valencia, Calif., killing actor Paul Walker on Saturday, Nov. 30, 2013. (Dan Watson / The Santa Clarita Valley Signal via AP)


People view a roadside memorial at the site of the auto crash that took the life of actor Paul Walker and another man, in the small community of Valencia, Calif., Monday, Dec. 2, 2013. (Nick Ut / AP)


Photos and messages are seen at a roadside memorial at the site of the auto crash that took the life of actor Paul Walker and another man, in the small community of Valencia, Calif., Monday, Dec. 2, 2013. (Nick Ut / AP)


A man views flowers and memorials at a roadside memorial at the site of the auto crash that took the life of actor Paul Walker and another man, in the small community of Valencia, Calif., Monday, Dec. 2, 2013. (Nick Ut / AP)


Marjan Bauman, right, and her daughter Alexandra Bauman join others at the site of the auto crash that took the life of actor Paul Walker and another man, in the small community of Valencia, Calif., Monday, Dec. 2, 2013. (Nick Ut / AP)


Sheriff's deputies work near the wreckage of a Porsche that crashed into a light pole in Valencia, Calif., on Saturday, Nov. 30, 2013. A publicist for actor Paul Walker says the star of the "Fast & Furious" movie series died in the crash north of Los Angeles. He was 40. (Dan Watson / Santa Clarita Valley Signal via The AP)


Writer-director Eric Heisserer, left, and actor Paul Walker discuss a scene on the New Orleans set of the Hurricane Katrina drama 'Hours.'


Paul Walker, left, Dwayne Johnson and Vin Diesel are all back in action in the sequel 'Fast & Furious 6.'

LOS ANGELES -- The Porsche carrying "Fast & Furious" star Paul Walker may have been going 100 mph or more before it crashed, killing both Walker and the driver, according to a coroner's report released Friday. Investigators found no mechanical problems with the 2005 Porsche Carrera GT or debris or other problems on the roadway.
The street forms an approximately 1-mile loop amid industrial office parks and is rimmed by hills and isolated from traffic, especially on weekends. The downed light pole the car hit had a speed limit sign of 45 mph. The area in Santa Clarita is about 30 miles northwest of downtown Los Angeles.
Roger Rodas, Walker's friend and financial adviser, was driving the Porsche at an unsafe speed, and witnesses interviewed by deputies estimated it was going 100 mph or more.
No alcohol or drugs were detected in the system of either man on the day of the fiery one-car crash.
The Nov. 30 deaths were ruled accidents and were due to combined traumatic and thermal injuries, the report said. It said both men were burned over 100 percent of their bodies.
Rodas had fourth-degree burns on his head and neck and severe skull fractures, the report said.
Walker had broken bones throughout his body including his jaw, arm, ribs and pelvis, it said.
Paul Walker discusses his New Orleans-shot thriller 'Hours' (audio) Film scheduled to open in theaters and on VOD platforms Dec. 13, just two weeks after actor's tragic death

The car slammed into a tree and a light pole on the driver's side then after spinning, hit a second tree on Walker's side of the car and caught fire.
The report says the red Porsche was traveling "at an unsafe speed, approximately 100+ mph," according to a deputy who took testimony from witnesses at the scene. "For unknown reasons, the driver lost control of his vehicle," the report says.
The Sheriff's Department had previously cited speed as a factor in the crash, but had released no estimate of how fast the Porsche was going. Sheriff's investigators are working with Porsche officials and the California Highway Patrol to determine the speed more exactly. Three data recorders survived the crash and fire and may produce information to pinpoint the speed.
Rodas, 38, and Walker, 40, co-owned an auto racing team. Rodas also was a professional driver who competed in 10 Pirelli World Challenge GTS races last year.
The accident occurred while Walker was on a break after shooting about half of "Fast & Furious 7," whose release Universal Pictures has now delayed for almost a year to April 2015. Walker still will appear in the film, though Universal has not said exactly how it will handle his unfinished performance.
Also Friday, two men pleaded not guilty to stealing a roof panel of the wrecked Porsche from the tow truck removing it from the accident scene.

Anthony Edward Janow, 25, and James Brooks Witty, 18, were each charged with felony counts of grand theft and misdemeanor counts of destroying evidence and resisting or obstructing a peace officer. They are due to return to court Feb. 25.

10 movies to watch for in 2014



10. 'The Hobbit: There and Back Again.' Director Peter Jackson lost me with last year’s 'The Hobbit: An Unexpected Journey' -- but then he went and won me back with this year’s 'The Hobbit: The Desolation of Smaug' as seen above). Can't wait to see what's next. Release date: Dec. 17, 2014.



9. '22 Jump Street.' The first one was such a pleasant surprise, but now the New Orleans-shot sequel arrives with what could be a curse: high expectations. If anybody can raise the bar, however, you'��ve got to think that Jonah Hill and Channing Tatum can. Release date: June 13, 2014.



8. 'The Monuments Men.' The studio’s decision to move this George Clooney-directed World War II thriller out of Oscar season speaks volumes, but with a cast that includes John Goodman, Matt Damon, Cate Blanchett and Clooney, I can’t help but be intrigued. Release date: Feb. 7, 2014.



7. 'Labor Day.' The reliable Jason Reitman directs a drama, starring Josh Brolin and Kate Winslet, about a single mother and son who befried a mysterious stranger -- as the police launch a manhunt for an escaped convict. Release date: Jan. 31, 2014.



6. 'Jupiter Ascending.' The always-interesting Wachowski siblings are back, with a sci-fi spectacle about a janitor who finds out that she might be The One. Release date: July 18.



5. 'The Grand Budapest Hotel.' Wes Anderson does the Wes Anderson thing -- that is, tell a story of colorful, quirky characters in a colorful, quirky setting. This time, it centers on Gustave H (Ralph Fiennes), the concierge at a European hotel between the wars. Release date: March 7, 2014.



4. 'Lone Survivor.' Mark Wahlberg suits up for a military drama, about a team of SEALs on a mission destined to fail. Peter Berg directs a story that, based on real events, promises to be powerful stuff. Release date: Jan. 10, 2014.



3. 'Her.' Spike Jonze directs Joaquin Phoenix in a trippy romance, set in the near future, in which a man falls in love with his computer operating system. If nothing else, it will be different. Release date: Jan. 10, 2014.



2. 'Dawn of the Planet of the Apes.' The recent arrival of this New Orleans-shot sequel to 'Rise of the Planet of the Apes' only made me want to see it more. Release date: July 11, 2014.



1. 'Interstellar.' Christopher Nolan (shown here on the set of 'The Dark Knight Rises') sends audiences -- as well as Matthew McConaughey, Anne Hathaway, Jessica Chastain and Casey Affleck -- on a deep-space voyage prompted by the discovery of a wormhole. Yes, please. Release date: Nov. 7, 2014.